Altered Esophageal Smooth Muscle Phenotype in Achalasia.
David Mario RodriguesSandra R LourenssenJay KatariaWilliam G PatersonMichael G BlennerhassettRobert BecharaPublished in: Journal of neurogastroenterology and motility (2023)
The thickened circular smooth muscle layer in achalasia is largely denervated, with an altered contractile phenotype and fibrosis. Biopsies obtained during peroral endoscopic myotomy provide a means to further study the pathophysiology of achalasia.