Proteomics analysis of lysine crotonylation and 2-hydroxyisobutyrylation reveals significant features of systemic lupus erythematosus.

Ting XieJingjing DongXianqing ZhouDonge TangDandan LiJiejing ChenYumei ChenHuixuan XuWen XueDongzhou LiuXiaoping HongFang TangLianghong YinYong Dai

Published in: Clinical rheumatology (2022)

Kcr and Khib may promote the antigen presentation and jointly regulate the tissue damage mediated by leukocyte migration in SLE patients, which may play key roles in the pathogenesis of SLE probably. Key Points • Antigen processing and presentation and leukocyte transendothelial migration may play key roles in the pathogenesis of SLE.

Keyphrases

systemic lupus erythematosus
disease activity
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
mass spectrometry
case report
oxidative stress
peritoneal dialysis
prognostic factors
peripheral blood
patient reported