Risk Assessment for Hip and Knee Osteoarthritis Using Polygenic Risk Scores.
Bahareh Sedaghati-KhayatCindy G BoerJos RunhaarSita M A Bierma-ZeinstraLinda BroerM Arfan IkramEleftheria ZegginiAndré G UitterlindenJeroen G J van RooijJoyce B J van MeursPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Our findings validated the association of PRS across OA definitions. Since OA is becoming frequent and primary prevention is not commonly applicable, PRS-based risk assessment could play a role in OA prevention. However, the utility of PRS is dependent on the setting. Further studies are needed to test the integration of genetic risk assessment in diverse health care settings.