Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α.

Zuen RenMalindrie DharmaratneHuizhi LiangOuthiriaradjou BenardMiriam Morales-GallegoKimita SuyamaViney KumarAtefeh Taherian FardAmeya S KulkarniMichael PrystowskyJessica C MarLarry NortonRachel B Hazan

Published in: British journal of cancer (2024)

Collectively, these results underscored a dramatic effect of redox signaling on p63 activation by HIF1α, underlying phenotypic and metabolic plasticity leading to mammary tumour metastasis.

Keyphrases

endothelial cells
electron transfer