Effects of dopaminergic depletion and brain atrophy on neuropsychiatric symptoms in de novo Parkinson's disease.
Byoung Seok YeSeun JeonSohoon YoonSeong Woo KangKyoungWon BaikYoonju LeeSu Jin ChungJungsu S OhHyojeong MoonJae Seung KimPhil Hyu LeeYoung Ho SohnPublished in: Journal of neurology, neurosurgery, and psychiatry (2017)
The results of this study suggested that accumbens atrophy and frontotemporal cortical thinning, especially frontal cortical thinning, independently contributed to neuropsychiatric symptoms in patients with PD, while DAT uptake did not affect the neuropsychiatric symptoms.