Identification of Novel Genomic Loci for Anxiety and Extensive Genetic Overlap with Psychiatric Disorders.

Markos TesfayePiotr JaholkowskiAlexey A ShadrinGuy F L HindleyBørge HolenNadine ParkerPravesh ParekhZillur RahmanShahram BahramiGleda KutrolliOleksandr FreiSrdjan DjurovicAnders M DaleOlav B SmelandKevin S O'ConnellOle Andreas Andreassen

Published in: medRxiv : the preprint server for health sciences (2023)

Anxiety is a highly polygenic phenotype with extensive genetic overlap with psychiatric disorders. These genetic overlaps enabled the identification of novel loci for anxiety and shared loci with psychiatric disorders. The shared genetic architecture may underlie the comorbidity of anxiety, and the identified genetic loci implicate molecular pathways that could become potential drug targets.

Keyphrases

genome wide
copy number
dna methylation
sleep quality
genome wide association study
genome wide association
gene expression
risk assessment
adverse drug