Treponema pallidum membrane protein Tp47 promotes angiogenesis through ROS-induced autophagy.

Wei LiLin XieQiu-Ling LiQiu-Yan XuLi-Rong Lin Li-Li Liu Tian-Ci Yang

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)

Tp47-induced NADPH oxidase enhanced intracellular ROS production via mitochondrial ROS and promoted angiogenesis through autophagy mediated by ROS. These findings may contribute to our understanding of pathological angiogenesis in syphilis.

Keyphrases

cell death
reactive oxygen species
endothelial cells
high glucose
dna damage
oxidative stress
diabetic rats
vascular endothelial growth factor
endoplasmic reticulum stress
signaling pathway
wound healing
drug induced
men who have sex with men
hepatitis c virus