Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension.
Danchen WuRoss D Jansen-van VuurenAsish DasguptaRuaa Al-QazaziKuang-Hueih ChenAshley MartinJeffrey D MewburnElahe AlizadehPatricia Daniele Azevedo LimaOliver JonesPierce ColpmanNolan M BreaultIsaac M EmonLuka JedlovčnikYuan Yuan ZhaoMichael WellsGopinath SutendraStephen L ArcherPublished in: bioRxiv : the preprint server for biology (2023)
Drpitor1a inhibits Drp1 GTPase, reduces mitochondrial fission, and inhibits cell proliferation in PAH hPASMC. Drpitor1a caused no toxicity in MCT-PAH and had no significant effect on normal rats or hPASMCs. Drpitor1a is a potential PAH therapeutic which displays an interesting therapeutic sexual dimorphism.