Evaluation of tissue-clearing techniques for intraorgan imaging of distribution of polymeric nanoparticles as drug carriers.

Kiyomi Ishizawa Kohei Togami Hitoshi Tada Sumio Chono

Published in: Drug development and industrial pharmacy (2020)

The intraorgan imaging method was established using modified CUBIC technique by the intravenous administration of fluorescence-tagged tomato lectin for evaluating the distribution of polymeric nanoparticles in mouse pigment-rich organs.

Keyphrases

high resolution
drug delivery
cancer therapy
drug release
high dose
single molecule
emergency department
photodynamic therapy
adverse drug