Kallikrein augments the anticoagulant function of the protein C system in thrombin generation.

Jun Wan Nadira VadaqJoke KoningsMartin JaegerVinod KumarBas de LaatLeo JoostenMihai G NeteaAndre J van der VenPhilip G de GrootQuirijn de MastMark Roest

Published in: Journal of thrombosis and haemostasis : JTH (2021)

Our results suggest that kallikrein plays a role in the regulation of the anticoagulant protein C pathway in TG, which may provide a novel mechanism for the previously observed association between the KLKB1 gene and venous thrombosis.

Keyphrases

atrial fibrillation
venous thromboembolism
protein protein
binding protein
genome wide
gene expression
small molecule