The Impact of Zinc on Manganese Bioavailability and Cytotoxicity in HepG2 Cells.

Vivien MichaelisSilja KasperLisa NaperkowskiJan PusseAlicia ThielFranziska EbertMichael AschnerTanja SchwerdtleHajo HaaseJulia Bornhorst

Published in: Molecular nutrition & food research (2023)

Zn protects against Mn-induced cytotoxicity in HepG2 cells possibly due to decreased Mn bioavailability. Additionally, mRNA expression of metal homeostasis-related genes indicates possible underlying pathways that should to be addressed in future studies.

Keyphrases

oxide nanoparticles
room temperature
high glucose
diabetic rats
transition metal
metal organic framework
current status
heavy metals
case control
oxidative stress