Positive Allosteric Modulation of NMDARs Prevents the Altered Surface Dynamics Caused by Patients' Antibodies.

Estibaliz Maudes Zoë JametLaura MarmolejoJosep O Dalmau Laurent Groc

Published in: Neurology(R) neuroimmunology & neuroinflammation (2024)

We demonstrate that SGE-301 upregulates NMDAR surface diffusion and antagonizes the pathogenic effects of patients' IgG on NMDAR membrane organization. These findings suggest a potential therapeutic strategy for NMDARe.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
small molecule
patient reported outcomes