PDE5 inhibitor potentially improves polyuria and bladder storage and voiding dysfunctions in type 2 diabetic rats.

Takafumi KabutoSo InamuraHisato KobayashiXinmin ZhaKeiko NagaseMinekatsu TagaMasaya SekiNobuki TanakaYoshinaga OkumuraOsamu YokoyamaNaoki Terada

Published in: PloS one (2024)

The T2DM rats had polyuria, increased ATP release induced by decreased bladder blood flow and impaired contractile function. PDE5 inhibition improved these changes and may prevent T2DM-associated urinary frequency and bladder storage and voiding dysfunctions.

Keyphrases

blood flow
diabetic rats
spinal cord injury
oxidative stress
urinary tract
skeletal muscle
metabolic syndrome
insulin resistance
adipose tissue