Glomerular hyperfiltration in morbid obesity: Role of the inflammasome signalling.
Diego MoriconiLuca AntonioliStefano MasiRosario BelliniCarolina PellegriniEleni RebelosStefano TaddeiMonica NannipieriPublished in: Nephrology (Carlton, Vic.) (2022)
Weight loss is effective in reducing hyperfiltration in most, but not all patients. Hyperfiltration remains unchanged in subjects who do not have a reduction in IL-1β/Caspase-1, suggesting a pathogenetic role of the inflammasome signalling in the early stages of nephropathy.
Keyphrases
- weight loss
- bariatric surgery
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- metabolic syndrome
- type diabetes
- cell death
- insulin resistance
- peritoneal dialysis
- roux en y gastric bypass
- obese patients
- physical activity
- skeletal muscle
- adipose tissue
- high fat diet induced
- glycemic control