Burden of neurological and neurocognitive impairment in pediatric sickle cell anemia in Uganda (BRAIN SAFE): a cross-sectional study.
Federico VerzegnassiDeogratias MunubePaul BangiranaLinda Rosset BulumaBridget KebirungiRobert OpokaEzekiel MuperePhilip KasiryeSarah KiguliAnnet BirabwaMichael S KawooyaSamson K LubowaRogers SekibiraEdwards KayongoHeather HumeMitchell ElkindWeixin PengGen LiCaterina RosanoPhilip LaRussaFrank J MinjaAmelia BoehmeRichard IdroPublished in: BMC pediatrics (2019)
The high frequency of neurocognitive impairment or other abnormal results describes a large burden of pediatric SCA brain disease in Uganda. Evaluation by any single modality would have underestimated the impact of SCA. Testing the impact of hydroxyurea or other available disease-modifying interventions for reducing or preventing SCA brain effects is warranted.