Human milk oligosaccharides (HMOs) have been recognized as gold standard for infant development. 3-Fucosyllactose (3-FL), being one of the Generally Recognized as Safe HMOs, represents a core trisaccharide within the realm of HMOs; however, it has received comparatively less attention in contrast to extensively studied 2'-fucosyllactose. The objective of this review is to comprehensively summarize the health effects of 3-FL, including its impact on gut microbiota proliferation, antimicrobial effects, immune regulation, antiviral protection, and brain maturation. Additionally, the discussion also covers the commercial application and regulatory approval status of 3-FL. Lastly, an organized presentation of large-scale production methods for 3-FL aims to provide a comprehensive guide that highlights current strategies and challenges in optimization.
Keyphrases
- human milk
- low birth weight
- preterm infants
- healthcare
- public health
- magnetic resonance
- working memory
- mental health
- signaling pathway
- staphylococcus aureus
- preterm birth
- transcription factor
- white matter
- magnetic resonance imaging
- case report
- health information
- resting state
- risk assessment
- contrast enhanced
- social media
- health promotion
- blood brain barrier
- subarachnoid hemorrhage
- solid state