Enteric RET inhibition attenuates gastrointestinal secretion and motility via cholinergic signaling in rat colonic mucosal preparations.
John P RussellEhsan MohammadiCasey O LigonRocco LatorreAnthony C JohnsonBao HoangDavid KrullMelisa W-Y HoHilary S EidamMichael P DeMartinoMui CheungAllen I OliffSanjay KumarBeverley Greenwood-Van MeerveldPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)
Our findings provide evidence that RET-mediated mechanisms regulate colonic function by maintaining cholinergic neuronal function and enabling ACh-evoked chloride secretion and motility. We suggest that modulating the cholinergic control of the colon via a RET inhibitor may represent a novel target for the treatment of intestinal disorders associated with increased secretion and accelerated GI transit such as irritable bowel syndrome with diarrhea (IBS-D).