Zoledronate Causes a Systemic Shift of Macrophage Polarization towards M1 In Vivo.

Manuel Weber Andi HommStefan MüllerSilke FreyKerstin AmannJutta RiesCarol GeppertRaimund PreidlTobias MöstPeer Wolfgang KämmererMarco KestingFalk Wehrhan

Published in: International journal of molecular sciences (2021)

BP application leads to a systemic pro-inflammatory situation in vivo, independent of surgical trauma, as evidenced by the shift in macrophage polarization towards M1 in various somatic tissues. This provides a possible explanation for the clinically observed anti-tumor effect of bisphosphonates and might also contribute to pathogenesis of MRONJ.

Keyphrases

gene expression
copy number
trauma patients