Genome-wide whole blood transcriptome profiling in a large European cohort of systemic sclerosis patients.

Lorenzo BerettaGuillermo BarturenBarbara VigoneChiara BellocchiNicolas HunzelmannEllen De LangheRicard CerveraMaria GerosaLászló KovácsRafaela Ortega CastroIsabel AlmeidaDivi CornecCarlo ChizzoliniJacques-Olivier PersZuzanna MakowskaRalf LescheMartin KerickMarta Eugenia Alarcón-RiquelmeJavier Martinnull nullnull null

Published in: Annals of the rheumatic diseases (2020)

We discovered a set of differentially expressed genes/pathways validated in two independent sets of patients with SSc, highlighting a number of deregulated processes that have relevance for the pathogenesis of autoimmunity and SSc.

Keyphrases

systemic sclerosis
genome wide
interstitial lung disease
end stage renal disease
dna methylation
ejection fraction
chronic kidney disease
single cell
newly diagnosed
peritoneal dialysis
gene expression
prognostic factors
copy number
transcription factor
bioinformatics analysis