Mitigation of Sepsis-Induced Acute Lung Injury by BMSC-Derived Exosomal miR-125b-5p Through STAT3-Mediated Suppression of Macrophage Pyroptosis.
Yi-Ming TaoXinxin XuBin YangHui ZhaoYongsheng LiPublished in: International journal of nanomedicine (2023)
Exosomes derived from BMSCs, serving as carriers for delivering miR-125b-5p, can downregulate STAT3, thereby inhibiting macrophage pyroptosis and alleviating sepsis-associated ALI. These significant findings provide valuable insights into the potential development of ALI therapies centred around exosomes derived from BMSC.
Keyphrases
- mesenchymal stem cells
- septic shock
- acute kidney injury
- nlrp inflammasome
- intensive care unit
- stem cells
- cell proliferation
- adipose tissue
- lipopolysaccharide induced
- high glucose
- climate change
- diabetic rats
- lps induced
- signaling pathway
- inflammatory response
- drug induced
- human health
- bone marrow
- risk assessment
- endothelial cells