Oscillatory Shear Stress Induces Oxidative Stress via TLR4 Activation in Endothelial Cells.
Zhimei WangFeng WangXiang-Quan KongXiao-Fei GaoYue GuJun-Jie ZhangPublished in: Mediators of inflammation (2019)
TLR4 modulates OSS-induced oxidative stress by activating NOX2 and suppressing eNOS.
Keyphrases
- endothelial cells
- toll like receptor
- oxidative stress
- inflammatory response
- signaling pathway
- immune response
- pi k akt
- high frequency
- hydrogen peroxide
- high glucose
- nuclear factor
- dna damage
- induced apoptosis
- nitric oxide synthase
- vascular endothelial growth factor
- reactive oxygen species
- diabetic rats
- nitric oxide
- endoplasmic reticulum stress