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The mitochondrial DNA content of cumulus cells may help predict embryo implantation.

A TaugourdeauV Desquiret-DumasJ F HamelS ChupinL BoucretV Ferré-L'HotellierP E BouetP DescampsV ProcaccioP ReynierPascale May-Panloup
Published in: Journal of assisted reproduction and genetics (2018)
During in vitro fertilization (IVF) procedures, the probability of the implantation of the embryo appears to be closely correlated to the mtDNA copy numbers in the CGCs. Our results highlight the interest of mtDNA quantification in GCGs as a biomarker of the potential of embryo implantation.
Keyphrases
  • mitochondrial dna
  • copy number
  • pregnancy outcomes
  • induced apoptosis
  • cell cycle arrest
  • genome wide
  • pregnant women
  • endoplasmic reticulum stress
  • gene expression
  • oxidative stress
  • cell death
  • signaling pathway