Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status.
Leena ÄyräväinenAnna Maria HeikkinenAntti KuulialaKirsi AholaRiitta KoivuniemiLeena LaasonenEeva MoilanenMari HämäläinenTaina TervahartialaJukka H MeurmanMarjatta Leirisalo-RepoTimo SorsaPublished in: Annals of medicine (2018)
Elevated serum concentrations of MMP-8 and IL-6 in CRA patients reflected chronic RA, while elevated salivary concentrations of MMP-8 levels in ERA patients reflected increased periodontal inflammation. Key messages Concentrations of inflammatory biomarkers in serum and saliva were different between patients with RA and healthy controls. Concentrations of MMP-8 and of IL-6 in serum were elevated in patients with chronic RA reflecting joint inflammation and the burden of established RA. Concentrations of MMP-8 in saliva was elevated already at the early stage of RA and the level of salivary MMP-8 was associated with poor periodontal health both in patients with early and in those with chronic RA.
Keyphrases
- rheumatoid arthritis
- end stage renal disease
- oxidative stress
- early stage
- disease activity
- ejection fraction
- newly diagnosed
- chronic kidney disease
- ankylosing spondylitis
- prognostic factors
- mental health
- squamous cell carcinoma
- systemic lupus erythematosus
- interstitial lung disease
- health information
- social media
- idiopathic pulmonary fibrosis