Coronavirus Host Genetics South Africa (COHG-SA) database-a variant database for gene regions associated with SARS-CoV-2 outcomes.
Fatima BarmaniaJuanita MelletMegan A RyderGraeme R FordCandice L HerdTsaone TamuhlaCandice Laverne HendricksRachel GilesThumbiko KaluaFourie JoubertNicki TiffinMichael Sean PepperPublished in: European journal of human genetics : EJHG (2022)
The SARS-CoV-2 virus is responsible for the COVID-19 global public health emergency, and the disease it causes is highly variable in its clinical presentation. Clinical phenotypes are heterogeneous both in terms of presentation of symptoms in the host and response to therapy. Several studies and initiatives have been established to analyse and review host genetic epidemiology associated with COVID-19. Our research group curated these articles into a web-based database using the python application-server framework Django. The database provides a searchable research tool describing current literature surrounding COVID-19 host genetic factors associated with disease outcome. This paper describes the COHG-SA database and provides an overview of the analyses that can be derived from these data.
Keyphrases
- sars cov
- public health
- respiratory syndrome coronavirus
- coronavirus disease
- adverse drug
- south africa
- genome wide
- copy number
- emergency department
- systematic review
- gene expression
- dna methylation
- stem cells
- risk factors
- machine learning
- adipose tissue
- electronic health record
- type diabetes
- big data
- quality improvement
- transcription factor
- bone marrow
- human immunodeficiency virus
- physical activity
- artificial intelligence
- sleep quality
- protein protein
- case control
- emergency medical
- antiretroviral therapy