Diagnostic accuracy of a novel tuberculosis point-of-care urine lipoarabinomannan assay for people living with HIV: A meta-analysis of individual in- and outpatient data.
Tobias BrogerMark P NicolRita SzékelyStephanie BjerrumBianca SossenCharlotte SchutzJapheth A OpintanIsik S JohansenSatoshi MitaraiKinuyo ChikamatsuAndrew D KerkhoffAurélien MaceStefano OngarelloGraeme MeintjesClaudia M DenkingerSamuel G SchumacherPublished in: PLoS medicine (2020)
In this study, we found that SILVAMP-LAM identified a substantially higher proportion of TB patients in PLHIV than LF-LAM. The sensitivity of SILVAMP-LAM was highest in patients with CD4 count ≤ 100 cells/μl. Further work is needed to demonstrate accuracy when implemented as a point-of-care test.
Keyphrases
- end stage renal disease
- mycobacterium tuberculosis
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- high throughput
- electronic health record
- cell cycle arrest
- hiv aids
- big data
- cell proliferation
- hiv infected
- artificial intelligence
- signaling pathway
- hepatitis c virus
- human immunodeficiency virus
- nk cells