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Diagnostic accuracy of a novel tuberculosis point-of-care urine lipoarabinomannan assay for people living with HIV: A meta-analysis of individual in- and outpatient data.

Tobias BrogerMark P NicolRita SzékelyStephanie BjerrumBianca SossenCharlotte SchutzJapheth A OpintanIsik S JohansenSatoshi MitaraiKinuyo ChikamatsuAndrew D KerkhoffAurélien MaceStefano OngarelloGraeme MeintjesClaudia M DenkingerSamuel G Schumacher
Published in: PLoS medicine (2020)
In this study, we found that SILVAMP-LAM identified a substantially higher proportion of TB patients in PLHIV than LF-LAM. The sensitivity of SILVAMP-LAM was highest in patients with CD4 count ≤ 100 cells/μl. Further work is needed to demonstrate accuracy when implemented as a point-of-care test.
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