Mechanisms of antihypertensive effect of chlorthalidone in advanced chronic kidney disease-a causal mediation analysis.
Rajiv AgarwalArjun D SinhaWanzhu F TuPublished in: Clinical journal of the American Society of Nephrology : CJASN (2024)
Chlorthalidone improved BP control among patients with advanced CKD independently of baseline urinary sodium, aldosterone, weight loss, or changes in the renin-angiotensin system or NT-pro BNP. (Funded by the National Heart Lung and Blood Institute; CLICK ClinicalTrials.gov number, NCT02841280).