Cardiovascular remodeling as a result of fibroblast growth factor-23 (FGF-23)/Klotho imbalance in patients with CKD.
Ludmila Yu MilovanovaMarina V TaranovaSvetlana Yu MilovanovaLidia V Kozlovskaya LysenkoAnastasia I PasechnikVasiliy V KozlovVladimir D BeketovAlexey V VolkovMikhail RatanovPublished in: International urology and nephrology (2021)
In CKD patients without CVD clinical manifestation increased serum FGF-23 level and decreased Klotho are associated with CVR: FGF-23 with eccentric LVH (independently of CBP), Klotho determinate concentric LVH, PWV and CCS. Moderately elevated sTr-I levels may be a manifestation of FGF-23/Klotho imbalance in CKD.