sPDGFRβ and neuroinflammation are associated with AD biomarkers and differ by race: The ASCEND Study.

Brittany ButtsHanfeng HuangWilliam T HuPatrick Gavin KehoeJames Scott MinersDanielle D VerbleHenrik ZetterbergLiping ZhaoLynn Marie TrottiKarima BenameurLaura M ScorrWhitney Wharton

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

Cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers changed over 2 years in high-risk middle-aged adults. Markers of vascular dysfunction were associated with the CSF biomarkers amyloid beta and tau. AD biomarkers were lower in Black compared to non-Hispanic White individuals. Markers of vascular dysfunction were lower among Black individuals.

Keyphrases

cerebrospinal fluid
middle aged
oxidative stress
cognitive decline
african american
mild cognitive impairment
subarachnoid hemorrhage