STAT3 activation in circulating myeloid-derived cells contributes to retinal microvascular dysfunction in diabetes.
Mei ChenGideon ObasanmiDavid ArmstrongNuala-Jane LaveryAdrien KissenpfennigNoemi LoisHeping XuPublished in: Journal of neuroinflammation (2019)
STAT3 activation in circulating immune cells appears to contribute to retinal microvascular degeneration and may be involved in DR initiation in T1D.
Keyphrases
- optical coherence tomography
- diabetic retinopathy
- induced apoptosis
- cell proliferation
- type diabetes
- cardiovascular disease
- optic nerve
- oxidative stress
- cell cycle arrest
- dendritic cells
- bone marrow
- acute myeloid leukemia
- metabolic syndrome
- endoplasmic reticulum stress
- adipose tissue
- skeletal muscle
- editorial comment