Metformin limits osteoarthritis development and progression through activation of AMPK signalling.
Jun LiBin ZhangWei-Xiao LiuKe LuHaobo PanTingyu WangChun-do OhDan YiJian HuangLan ZhaoGuangzhi NingCong XingGuozhi XiaoRu Liu-BryanShiqing FengDi ChenPublished in: Annals of the rheumatic diseases (2020)
The present study suggests that metformin, administered shortly after joint injury, can limit OA development and progression in injury-induced OA animal models.