Exploring the mechanism of metformin action in Alzheimer's disease and type 2 diabetes based on network pharmacology, molecular docking, and molecular dynamic simulation.

Xin ShiLingling LiZhiyao LiuFangqi WangHailiang Huang

Published in: Therapeutic advances in endocrinology and metabolism (2023)

Metformin exerts its effects on regulating oxidative stress, gluconeogenesis and inflammation, which may be the mechanism of action of metformin to improve the common pathological features of T2D and AD.

Keyphrases

molecular docking
oxidative stress
type diabetes
molecular dynamics simulations
cognitive decline
ischemia reperfusion injury
diabetic rats
induced apoptosis
glycemic control
single molecule
signaling pathway
mild cognitive impairment
heat shock protein
weight loss