The effect of maternal polycyclic aromatic hydrocarbons exposure and methylation levels of congenital heart diseases-candidate genes on the risk of congenital heart diseases.

Nana LiLu LiZhen LiuYing DengMeixian WangJinju ZhaoShengli ZengHong KangYanping WangJun ZhuJianxin ZhaoPing Yu

Published in: Prenatal diagnosis (2022)

Maternal PAHs exposure was linked with CHDs. Higher methylation of the upstream sequence of NKX2-5 promoter decreased the risk of CHDs. There was no correlation between maternal PAHs exposure and the methylation level of NKX2-5.

Keyphrases

polycyclic aromatic hydrocarbons
dna methylation
birth weight
genome wide
pregnancy outcomes
gene expression
pregnant women
human health
health risk assessment
body mass index
gestational age
amino acid
preterm birth