WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models.

Jason E Conage-PoughSylwia A StopkaJu-Hee OhAnn C MladekDanielle M BurgenskeMichael S ReganGerard BaquerPaul A DeckerBrett L CarlsonKatrina K BakkenJinqiang ZhangLily LiuClaire SunZhihua MuWei ZhongNhan L TranWilliam F ElmquistNathalie Y R AgarJann N SarkariaForest M White

Published in: Neuro-oncology advances (2023)

WSD-0922 is a highly potent inhibitor of EGFR in GBM, and warrants further evaluation in clinical studies.

Keyphrases

epidermal growth factor receptor
tyrosine kinase
advanced non small cell lung cancer
mouse model
white matter
resting state
multiple sclerosis
functional connectivity
brain injury
anti inflammatory
blood brain barrier