Protective effect of pregabalin on the brain tissue of diabetic rats.

Caner Feyzi Demir Metin Balduz İrem Taşcı Tuncay Kuloglu

Published in: Diabetology international (2020)

Pregabalin may prevent harmful effects of oxidative damage by decreasing the MDA levels and increasing the SOD levels. In addition, it was thought that PGB may have antiapoptotic properties due to decreased bax and caspase-3 immunoreactivity and TUNEL positivity in PGB groups. Based on these findings, we think that PGB may be effective in reducing the risk of brain damage associated with DM.

Keyphrases

diabetic rats
oxidative stress
resting state
neuropathic pain
white matter
induced apoptosis
functional connectivity
cell death
cerebral ischemia
postoperative pain
spinal cord
spinal cord injury
type diabetes
metabolic syndrome
cell proliferation
brain injury
subarachnoid hemorrhage