Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer.
Elisa M LedetEarle F BurgessAlexandra O SokolovaEllen B JaegerWhitley HattonMarcus MosesPatrick MillerPatrick CotognoJodi LaytonPedro BarataBrian E LewisMari NakazawaJason ZhuBeth DellingerSara ElrefaiNellie N NafissiJan B EganNeal ShoreRana R McKayAlan H BryceHeather H ChengEmmanuel S AntonarakisA Oliver SartorPublished in: The Prostate (2021)
In metastatic prostate cancer patients, PV/LPVs of tested genes did not vary by race, BRCA1 PV/LPVs were more common in the African American subset. However, PV/LPVs in non-BRCA DNA repair genes were less likely to be encountered in African Americans. Family history associated with genetic testing results in Caucasians only.
Keyphrases
- african american
- dna repair
- prostate cancer
- dna damage
- squamous cell carcinoma
- small cell lung cancer
- genome wide
- radical prostatectomy
- dna damage response
- bioinformatics analysis
- genome wide identification
- breast cancer risk
- middle aged
- gene expression
- genome wide analysis
- benign prostatic hyperplasia
- transcription factor