Near-Infrared Guided Thermal-Responsive Nanomedicine against Orthotopic Superficial Bladder Cancer.
Hui GaoYing BiXin WangMiao WangMengxue ZhouHuiru LuJimin GaoJun ChenYi HuPublished in: ACS biomaterials science & engineering (2017)
Nanomedicines have shown great promise in increasing the efficacy and preventing adverse effects of drugs for bladder cancer. Here we sought to examine the effect of chemo-photothermal therapy on an orthotopic mouse model of superficial bladder cancer. Doxorubicin (DOX) was encapsulated in CS/PNIPAAm@SWCNTs nanoparticles. The biodistribution and antitumor effects of DOX-loaded nanoparticles were analyzed. DOX-loaded nanoparticles were accumulated in tumor cells upon near-infrared (NIR) irradiation and exhibited strong antitumor activity in mice bearing orthotopic bladder tumors. In addition, NIR-induced hyperthermia enhanced the permeability of tumor blood vessels, which presumably accounted for specific targeting of the nanomedicines to tumors. These results suggest that NIR-guided thermal-responsive nanomedicines are potentially applicable for chemo-photothermal therapy against orthotopic bladder tumors.
Keyphrases
- cancer therapy
- drug delivery
- photodynamic therapy
- drug release
- mouse model
- fluorescence imaging
- fluorescent probe
- spinal cord injury
- walled carbon nanotubes
- endothelial cells
- metabolic syndrome
- radiation induced
- adipose tissue
- locally advanced
- insulin resistance
- machine learning
- deep learning
- big data
- artificial intelligence