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Near-Infrared Guided Thermal-Responsive Nanomedicine against Orthotopic Superficial Bladder Cancer.

Hui GaoYing BiXin WangMiao WangMengxue ZhouHuiru LuJimin GaoJun ChenYi Hu
Published in: ACS biomaterials science & engineering (2017)
Nanomedicines have shown great promise in increasing the efficacy and preventing adverse effects of drugs for bladder cancer. Here we sought to examine the effect of chemo-photothermal therapy on an orthotopic mouse model of superficial bladder cancer. Doxorubicin (DOX) was encapsulated in CS/PNIPAAm@SWCNTs nanoparticles. The biodistribution and antitumor effects of DOX-loaded nanoparticles were analyzed. DOX-loaded nanoparticles were accumulated in tumor cells upon near-infrared (NIR) irradiation and exhibited strong antitumor activity in mice bearing orthotopic bladder tumors. In addition, NIR-induced hyperthermia enhanced the permeability of tumor blood vessels, which presumably accounted for specific targeting of the nanomedicines to tumors. These results suggest that NIR-guided thermal-responsive nanomedicines are potentially applicable for chemo-photothermal therapy against orthotopic bladder tumors.
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