NAFLD as the metabolic hallmark of obesity.
Alba RojanoElena SenaRamiro Manzano-NuñezJuan M PericàsAndreea CiudinPublished in: Internal and emergency medicine (2022)
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide, associated with a high risk of progression to NASH, liver cirrhosis and hepatocarcinoma. Its prevalence is closely related to obesity (understood as adipose-based disease and insulin resistance), which makes that at present NAFLD can be considered a metabolic dysfunction hallmark, regardless of the body mass index. Despite being such a prevalent condition, with such severe consequences, at present there are no reliable biomarkers for its diagnosis or specific treatment. Significant and sustained weight loss, as well as some antidiabetic treatments, has shown promising results for NAFLD but data needs confirmation in larger clinical trials and longer follow-up. Efforts should be made for a better and more accurate baseline diagnosis (including large-scale genetics), identification of patients at higher risk for progression to NASH as well as adequate treatment, to allow us to offer a personalized approach in NAFLD in the context of precision medicine.
Keyphrases
- insulin resistance
- weight loss
- metabolic syndrome
- body mass index
- clinical trial
- type diabetes
- weight gain
- bariatric surgery
- high fat diet induced
- risk factors
- roux en y gastric bypass
- mass spectrometry
- combination therapy
- big data
- high resolution
- physical activity
- drug induced
- study protocol
- replacement therapy
- open label
- phase ii
- phase iii