Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC.
Konstantinos DimitriadisJan MeisHermann NeugebauerKristian BarlinnBernhard NeumannGeorg GahnPiergiorgio LochnerBenjamin KnierSarah LindemannKurt Wolfram SühsKristina SzaboThomas PfefferkornIngo SchirotzekTobias FreilingerBassa BurcAlbrecht GüntherMatthias WittstockPatrick SchrammGernot ReimannJana GodauGabor NagyFatima B KoenigFabian EssigHartwig KlinkerChristian HartmannMoritz L SchmidbauerTim SteinbergLora LefterovaChristina KloseJulian Böselnull nullPublished in: Critical care (London, England) (2022)
Based on this well-characterized COVID-19 ICU cohort, that comprised 12.7% of all severe ill COVID-19 patients, neurologic manifestations increase mortality and morbidity. Since no reliable evidence of direct viral affection of the nervous system by COVID-19 could be found, these neurologic manifestations may for a great part be indirect para- or postinfectious sequelae of the infection or severe critical illness. Neurologic ICU complications should be actively searched for and treated.