Leucocyte-derived micro-RNAs as candidate biomarkers in Brugada syndrome.
Christian SteinbergNathalie GaudreaultAndreas I PapadakisCyndi HenryJean ChampagneFrançois PhilipponGilles O'HaraLouis BlierBenoit PlourdeIsabelle NaultKarine RoyJean-François SarrazinAlan SpatzYohan BossePublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
Brugada patients display a distinct miRNA expression profile compared with unaffected control individuals. There is also evidence that certain miRNAs (miR-145-5p and miR-585-3p) are associated with the symptom status of Brugada patients. The results suggest the principal utility of leucocyte-derived miRNAs as prognostic biomarkers for Brugada syndrome.