Association of IL-10 (- 1082 A/G) and IL-6 (- 174 G/C) gene polymorphism with type 2 diabetes mellitus in Ethiopia population.

Birhanu AyelignMarkos NegashHenok AndualemTadelo WondemagegnEyuel KassaTewodros ShibabawYonas AkaluMeseret Derbew Molla

Published in: BMC endocrine disorders (2021)

Our study revealed that genetic polymorphisms of IL-6 (- 174) GG genotype is the potential host genetic risk factors to T2DM. While, IL-10 (- 1082) AA genotype is negatively associated with T2DM. Therefore, IL-6 (- 174) and IL-10 (- 1082) genetic variation may be considered as a biomarker for early screening and diagnosis of T2DM.

Keyphrases

risk factors
gene expression
adipose tissue
dna methylation
risk assessment
skeletal muscle
insulin resistance
copy number