Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies.
Julius StraussMargaret E Gatti-MaysByoung Chul ChoAndrew HillSébastien SalasEdward McClayJason M RedmanHoussein Abdul SaterRenee N DonahueCaroline JochemsElizabeth LampingAndrea BurmeisterJennifer L MartéLisa M CordesMarijo BilusicFatima KarzaiLaureen S OjalvoGenevieve JehlP Alexander RolfeChristian S HinrichsRavi A MadanJeffrey SchlomJames L GulleyPublished in: Journal for immunotherapy of cancer (2021)
Bintrafusp alfa showed clinical activity and manageable safety and is a promising treatment in HPV-associated cancers. These findings support further investigation of bintrafusp alfa in patients with advanced, pretreated HPV-associated cancers.