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Co-culture models of endothelial cells, macrophages, and vascular smooth muscle cells for the study of the natural history of atherosclerosis.

Martin LiuSaurabhi SamantCharu Hasini VasaRyan M PedrigiUsama M OguzSangjin RyuTimothy WeiDaniel R AndersonDevendra K AgrawalYiannis S Chatzizisis
Published in: PloS one (2023)
We present three-cell co-culture models of human atherosclerosis. These models have the potential to allow cost- and time-effective investigations of the mechanobiology of atherosclerosis and new anti-atherosclerotic drug therapies.
Keyphrases
  • endothelial cells
  • vascular smooth muscle cells
  • cardiovascular disease
  • angiotensin ii
  • single cell
  • high glucose
  • cell therapy
  • type diabetes
  • induced pluripotent stem cells
  • human health