Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case-control study.

Gianmarco AbbadessaGiuseppina MieleAndrea Di PietroMaddalena SparacoRaffaele PalladinoIgnazio ArmettaGiovanna D'EliaFrancesca TrojsiElisabetta SignorielloGiacomo LusLuigi LavorgnaSimona Bonavita

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2021)

We found that MS patients carried more pro-hemostatic variants than healthy controls. An increasing number of unfavorable alleles might increase the likelihood of being in the MS group, in the cumulative analysis. Our findings encourage to evaluating these variants in a larger population-based cohort.

Keyphrases

multiple sclerosis
end stage renal disease
mass spectrometry
copy number
ejection fraction
ms ms
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
patient reported outcomes
anti inflammatory
data analysis