Follicular helper-T cells restore CD8+-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy.
Julie NiogretHélène BergerCédric RebeRomain MaryElise BallotCaroline TruntzerMarion ThibaudinValentin DerangèreChristophe HibosLéa HampeDavid RageotThéo AccogliPhilippe JoubertBertrand RoutyJames HarkerFrederique VegranFrançois GhiringhelliFanny ChalminPublished in: Journal for immunotherapy of cancer (2021)
This study provides evidence that CD8+/Tfh crosstalk is important in shaping antitumor immune response generated by immunotherapy.