Investigating Celastrol's Anti-DCM Targets and Mechanisms via Network Pharmacology and Experimental Validation.
Rui XiYongxin WanLihong YangJingying ZhangLiu YangShuai YangRui ChaiFengchen MuQiting SunRui YanZhifang WuSijin LiPublished in: BioMed research international (2022)
Celastrol may play a role in reversing energy remodeling, anti-inflammation, and oxidative stress via modulating p38 protein expression in the MAPK pathway, which have been shown in the treatment of DCM.