Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers.

Charles E MordauntDorothy A KiefferNoreene M ShibataAnna CzłonkowskaTomasz LitwinKarl-Heinz WeissYihui ZhuChristopher L BowlusSouvik SarkarStewart CooperYu-Jui Yvonne WanMohamed R AliJanine M LaSalleValentina Medici

Published in: Epigenetics & chromatin (2019)

We identified a disease-mechanism relevant epigenomic signature of WD that reveals new insights into potential biomarkers and treatments for this complex monogenic disease.

Keyphrases

end stage renal disease
chronic kidney disease
newly diagnosed
prognostic factors
gene expression
genome wide