Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD.

Claudia ColussiAlessia BertozziLucia LeoneMarco RinaudoRaimondo SollazzoFederica ConteElena PaccosiLuca NardellaGiuseppe AcetoDomenica Donatella Li PumaCristian RipoliMaria Gabriella VitaCamillo MarraMarcello D'AscenzoClaudio Grassi

Published in: Stem cell research & therapy (2024)

Our data suggest that the positive effect of Nup153 on neurogenesis is based on a complex regulatory network orchestrated by Nup153 and that this protein is a valuable disease target.

Keyphrases

neural stem cells
mouse model
protein protein
amino acid
transcription factor
big data
cerebral ischemia
machine learning
small molecule
young adults
brain injury
blood brain barrier
replacement therapy
artificial intelligence
subarachnoid hemorrhage