Immunomodulatory effects of colchicine on peripheral blood mononuclear cell subpopulations in human obesity: Data from a randomized controlled trial.

Tushar P PatelJordan A LevineDiana M ElizondoBrooke E ArnerArad JainAnkit SaxenaMaria Lopez-OcasioPradeep K DagurOlufisola FamuyiwaSuryaa GuptaZahra Sarrafan-ChaharsoughiAngelique BiancottoJ Philip McCoyAndrew Paul Demidowich Jack A Yanovski

Published in: Obesity (Silver Spring, Md.) (2023)

In adults with obesity, colchicine significantly affects circulating leukocyte populations involved in both innate and adaptive immune systems along with the associated inflammatory secretome.

Keyphrases

peripheral blood
insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
immune response
endothelial cells
cell therapy
electronic health record
big data
induced pluripotent stem cells
stem cells
skeletal muscle
body mass index
physical activity
machine learning