DNA polymerase stalling at structured DNA constrains the expansion of short tandem repeats.
Pierre MuratGuillaume GuilbaudJulian E SalePublished in: Genome biology (2020)
Our data support a model in which STR length in eukaryotic genomes results from a balance between expansion due to polymerase slippage at repeated DNA sequences and point mutations caused by error-prone DNA synthesis at DNA structures.