17-β estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms.

Federica FiliceEmanuel LauberKarl Jakob VörckelMarkus WöhrBeat Schwaller

Published in: Molecular autism (2018)

Our results suggest that the E2-linked amelioration of ASD-like behaviors is specifically occurring in PV+/- mice, indicating that PV upregulation is required for the E2-mediated rescue of ASD-relevant behavioral impairments.

Keyphrases

autism spectrum disorder
intellectual disability
high fat diet induced
attention deficit hyperactivity disorder
early onset
signaling pathway
type diabetes
sleep quality
metabolic syndrome
physical activity
adipose tissue
working memory